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Wound Healing

Effects of equal daily doses delivered by different power densities of low-level laser therapy at 670 nm on open skin wound healing in normal and corticosteroid-treated rats: a brief report

Lacjaková K, Bobrov N, Poláková M, Slezák M, Vidová M, Vasilenko T, Novotný M, Longauer F, Lenhardt L, Bober J, Levkut M, Sabol F, Gál P.
Lasers Med Sci. 2010 Sep;25(5):761-6. Epub 2010 May 23.

The optimal parameters for low-level laser therapy (LLLT) for wound healing are still open to discussion. Hence, our study was aimed at comparing the effects of different power densities of LLLT at 670 nm in rats. Four round full-thickness skin wounds were placed on the backs of 16 rats which were divided into two groups (non-steroid and steroid-treated). Three wounds were stimulated daily with a diode laser (daily dose 5 J/cm(2)) at different power densities (5, 15 and 40 mW/cm(2), respectively), and the fourth wound served as a control. Six days after surgery all animals were killed and samples removed for histological evaluation. Significant acceleration of fibroblast proliferation and new vessel formation was observed in wounds treated at the selected power densities. No significant differences were found in corticosteroid-treated rats. In conclusion, LLLT with the methodology used improved wound healing in non-steroid rats, but was not effective after corticosteroid-treatment.

Role of endogenous porphyrins in laser therapy of experimental skin wounds

Machneva TV, Bulgakova NN, Vladimirov IuA, Osipov AN.
Biofizika. 2010 May-Jun;55(3):532-8.

The role of endogenous porphyrins in the effect of laser irradiation on the superoxide dismutase (SOD) activity of wound exudate and rat leukocyte activity has been studied on models of aceptic incised skin wounds. Wounds were irradiated by a He-Ne laser (632.8 nm, 1.5 J/cm2) on the 2nd, 3rd, and 4th days after the beginning of the experiment. Irradiation effects were evaluated by the SOD activity (NBT test) and the activity of leukocytes of wound exudate (as a chemiluminescent response to opsonized zymosan). It was found that in animals subjected to laser irradiation, the SOD activity sharply increased. This effect depended on endogenous porphyrin concentration and was retained throughout the experiment. The SOD activity in unirradiated animals decreased from the 2nd to the 5th day of experiment. The evaluation of the activity of wound exudate leukocytes did not reveal any distrinct dependence of the effect on the concentration of endogenous porphyrins.

Laser therapy in the tissue repair process: a literature review

da Silva JP, da Silva MA, Almeida AP, Lombardi Junior I, Matos AP. PMID: 19764898 [PubMed - in process]
Photomed Laser Surg. 2010 Feb;28(1):17-21.

OBJECTIVE: Carry out a literature review on the use of laser therapy in the tissue repair process and address the different lasers and parameters used by the authors.

METHODS: A review was carried out of the literature from 1960 to 2008 in the Lilacs, Medline, and PubMed databases using the following key words: Laser Therapy, Wound Healing, and Tissue repair.

RESULTS: The most frequently used types of laser are helium neon (HeNe) lasers and diode lasers, including gallium-aluminum-arsenium (GaAlAs), arsenium-gallium (AsGa), and indium-gallium-aluminum-phosphide (InGaAlP) lasers. However, implementation of different protocols was found, with different materials and different activating wavelengths, thus making it difficult to compare results and choose the parameters of treatment.

CONCLUSIONS: The majority of authors report that laser therapy speeds up the process of tissue repair, but further studies are suggested to determine the best parameters to be used.

Laboratory Methods for Evaluating the Effect of Low Level Laser Therapy (LLLT) In Wound Healing

HAWKINS, D. AND ABRAHAMSE, H. Faculty of Health, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, South Africa, 2028. Received: December, 2004 Accepted: January, 2005

The basic tenet of laser therapy is that laser radiation has a wavelength dependent capability to alter cellular behaviour in the absence of significant heating. Low intensity radiation can inhibit as well as stimulate cellular activity. Laser therapy typically involves the delivery of 1-4J/cm 2 to treatments sites with lasers having output powers between 10mW and 90mW. There are two major areas of laser therapy research: the laboratory and the clinic. The laboratory presents the least ambiguous results. Here, although unsupported results do appear, the vast majority of published work finds clear evidence that laser irradiation alters cellular processes in a nonthermal, wavelength-dependent manner. Low energy laser irradiation alters the cellular function by effecting protein synthesis, cell growth and differentiation, cell motility, membrane potential and binding affinities, neurotransmitter release, ATP synthesis and prostaglandin synthesis. Laboratory findings provide scientific rati onale of laser therapy and the effect of laser therapy on cellular processes. This review outlines some of the current methods employed in the laboratory to measure the effect of low level laser therapy (LLLT) on cellular and molecular processes in the cell. This review briefly explains the different structural, cellular and molecular parameters and highlights some of the basic principles and protocols including specialized equipment requirements.

Low-level laser therapy (LLLT) efficacy in post-operative wounds

Herascu N, Velciu B, Calin M, Savastru D, Talianu C. National Institute of Research and Development for Optoelectronics INOE 2000, 1 Atomistilor St.PO Box MG5, 077125, Magurele-Bucharest, Romania. This e-mail address is being protected from spambots. You need JavaScript enabled to view it
J Clin Laser Med Surg. 2004 Feb;22(1):19-25.

OBJECTIVE: The aim of this paper was to investigate the efficacy of low-level laser radiation (LLLR) with wavelength of 904 nm on the stimulation of the healing process of postoperative aseptic wounds (early scar).

BACKGROUND DATA: Low-level laser therapy (LLLT) has been increasingly used to treat many disorders, including wounds. However, despite such increased clinical usage, there is still controversy regarding the efficacy of this wound treatment in curent clinical practice.

METHODS: LLLT has been used to treat cutting plague in the right instep and on the left foot. Both resulted from sutured wounds. The clinical evaluation by semiquantitative methods is presented. RESULTS: Clinical evaluation showed that the healing process of these postoperatively treated wounds has occurred and that the functional recovery of the patients (i.e., return to their ordinary life) was faster than without treatment.

CONCLUSION: LLLR with wavelength of 904 nm to stimulate postoperative aseptic wounds (early scar) is efficient in both cases of cutting plague.

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